The default .htaccess is

<IfModule mod_rewrite.c>
  Options +FollowSymlinks
  RewriteEngine On
  RewriteCond %{REQUEST_FILENAME} !-d
  RewriteCond %{REQUEST_FILENAME} !-f
  RewriteRule ^(.*)$ index.php/ [QSA,PT,L]
</IfModule>

At this time, visit http://mydomain.me/home/index... and directly report the error Failed to load resource: the server responded with a status of 404 (Not Found) as shown below

After adding index.php, http://mydomain.me/index.php/..., the page can be accessed, but the error is reported as shown below

After modifying .htaccess, it can be accessed without index.php, but an error is still reported, the same as the picture above.

<IfModule mod_rewrite.c>
 RewriteEngine on
 RewriteCond %{REQUEST_FILENAME} !-d
 RewriteCond %{REQUEST_FILENAME} !-f
 RewriteRule ^(.*)$ index.php?s=/ [QSA,PT,L]
</IfModule>

What is the reason? How to break it?