rosetta is a comprehensive software for simulating macromolecular structures; the software was first written in FORTRAN in 1998 for abinitio prediction of small proteins. It has now been rewritten using "C" as a Flexible, versatile applications, it includes tools for structure prediction, design, and reshaping of proteins and nucleic acids.
The operating environment of this tutorial: Windows 10 system, DELL G3 computer.
rosetta is a comprehensive software for simulating macromolecular structures. It was first written in FORTRAN in 1998 and used for abinitio prediction of small proteins. Now rewritten in C, it serves as a flexible, versatile application that includes tools for structure prediction, design, and reshaping of proteins and nucleic acids. Rosetta's web server has run billions of simulations for structure prediction and protein design.
Rosetta's web servers already run billions of simulations for structure prediction and protein design, and billions or even trillions more run on supercomputer clusters.
Researchers use Rosetta to better understand treatments for infectious diseases, cancer and autoimmune diseases. Further applications include the development of vaccines, new materials, targeted protein binders and enzyme design.
Rosetta was originally a structure prediction tool that has consistently performed well in CASP community-wide blind prediction training. It has grown to provide a variety of efficient sampling algorithms for exploring backbone, side-chain, and sequence space, and its advantages have been generalized to more community-wide exercises including RNA-puzzles and CAPRI. Rosetta has extensively tested energy scoring capabilities and encompasses an unparalleled range of applications from folding to docking to design.
Rosetta is freely available to academic and government laboratories, with over 10,000 free licenses in use. Also includes an active forum. To download Rosetta, please apply for a license.
If you're ready to give Rosetta a try, I recommend starting here and trying these tutorials.
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