MySQL의 문자열 필드의 경우 in을 사용할 때 따옴표가 없으면 성능 문제가 발생합니다.

select count(*) total from member_phone where phone in(1521xxx541,15845xxx412)

mysql> select count(*) total from member_phone where phone in(1521xxx541,15845xxx412);
+-------+
| total |
+-------+
|     1 | 
+-------+
1 row in set (2.76 sec)
mysql> select count(*) total from member_phone where phone in('1521xxx541','15845xxx412');
+-------+
| total |
+-------+
|     1 | 
+-------+
1 row in set (0.01 sec)
mysql> select count(*) total from member_phone where (phone='1521xxx541' or phone='15845xxx412');
+-------+
| total |
+-------+
|     1 | 
+-------+
1 row in set (0.00 sec)

mysql> explain select count(*) total from member_phone where phone in(1521xxx541,15845xxx412) \G;
*************************** 1. row ***************************
           id: 1
  select_type: SIMPLE
        table: member_phone
         type: index
possible_keys: phone
          key: phone
      key_len: 18
          ref: NULL
         rows: 6307075
        Extra: Using where; Using index
1 row in set (0.00 sec)
mysql> explain select count(*) total from member_phone where phone in('1521xxx541','15845xxx412') \G;
*************************** 1. row ***************************
           id: 1
  select_type: SIMPLE
        table: member_phone
         type: range
possible_keys: phone
          key: phone
      key_len: 18
          ref: NULL
         rows: 2
        Extra: Using where; Using index
1 row in set (0.00 sec)
mysql> explain select count(*) total from member_phone where (phone='1521xxx541' or phone='15845xxx412') \G;
*************************** 1. row ***************************
           id: 1
  select_type: SIMPLE
        table: member_phone
         type: range
possible_keys: phone
          key: phone
      key_len: 18
          ref: NULL
         rows: 2
        Extra: Using where; Using index
1 row in set (0.01 sec)