Since this specific error message may be caused by a bug or some lower-level conflict, it may be tidied up in a future update of Safari or MacOS. Nonetheless, there are a few tricks you can apply to fix the problem on your Mac for the time being, or at least fix it.
Many users have reported that disabling IP address hiding in Safari and then restarting their Mac solved their problem.
Some users found that the Third-party firewall applications may be associated with error messages, so disabling them will stop NSPOSIXErrorDomain from appearing.
The process for disabling an application-level firewall or antivirus application varies by application, but if you're running one of these, try disabling it, restarting your Mac, and using Safari for a while to see Does it make a difference.
Some users have reported that disabling Safari extensions has resolved their issues.
A temporary fix is to restart the Mac, which tends to make the error message go away for a while, but for many users it will pop up again in time after using Safari Appear.
Go to the Apple menu and select "Restart"
If you can't make the error go away and it's stranding you, This is understandable because once the error starts it makes Safari almost useless, then using other web browsers like Chrome, Firefox, Brave or Edge is an option.
You can set any browser as your default web browser, whether it's Chrome, Brave, or another browser, and switch back to Safari at any time if you wish.
Finally, be sure to update macOS system software if you have an update available. Presumably whatever the underlying bug or issue is (if it's not already resolved with the newly released Monterey 12.2 or Safari 15.3).
Go to Apple Menu > System Preferences > Software Update
It's not entirely clear what causes this error, as not all users are affected, and some affected users are only temporarily affected, while others suffer from it permanently.
Perhaps worth noting, or just a random coincidence, but the error message code "NSPOSIXErrorDomain:28" itself may provide some hints as to what the underlying problem may be, since POSIX, which stands for Portable Operating System Interface, is a broad Computing standards for the API indicate that it may be a fairly low-level issue in Safari or macOS itself.
It's important to note that not everyone can reliably reproduce this error, and simply having many browser tabs or windows open will not cause the problem to occur. In the context of the general disk drive capacity on the affected Macs, the part of the error message stating "no space remaining on the device" is actually not correct, as no disk space issues are occurring and there are no apparent swap/virtual machine limitations .
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